Artistic people are often amused by a 1970s retro vibe, and we are lucky enough to have several choices in the area. For a look at the good old days of Detroit gangsters and your grandparents' idea of a "supper club" I would recommend Angelo's Northwood Grill on Dixie Highway in Erie, MI. The food's good, and when I've been there I stare around with amazement at the retro decor.
J&G's Pizza in Sylvania is another place that looks like it was decorated in about 1975 and then left perfectly preserved. The food is pretty straightforward casual Italian, but again, I enjoy the blast from the past.
For breakfast, I would consider Rick's Original City Diner on Bancroft near the UT campus. Good breakfast choices, nice CLEAN interior (which you don't always find in Toledo breakfast joints :-( and I enjoy the mixed clientele: students, neighborhood folks, church groups, even some bachelors ogling the waitresses. It's the kind of peoplewatching mix you find in bigger cities. And good food.
I don't know if the above satisfy the requirement for local food, fresh, creative cuisine ... but all three are a blast!
If schedule permits, I would definitely go to Grumpy's for awesome food and the beautiful interior ... and KoreaNa on Reynolds, for something different (and for the woodworkers-gone-wild interior).