Guitar Hero always reminded me of Simon, now there's something coming out that sounds way more advanced and lifelike. You can use a real guitar on your PC or Mac. Instead of the normal 5 minutes of fun of GH, you might be actually able to learn a chord or song or 2, as long as it's not Eric Clapton rimshot
http://www.guitarrising.com/index.html
http://gizmodo.com/352800/guitar-rising-for-real-guitar-heroes